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What is an Integrative Approach to Cancer Treatment?

Published by Connealy, MD on December 4, 2025

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Conventional cancer treatment typically involves chemotherapy, radiation, or surgery to remove the tumor. A growing tumor can press on organs, block blood flow, interfere with digestion or breathing, and produce large amounts of lactic acid that stress the body. In these situations, reducing the tumor load is necessary for safety, relieving symptoms caused by tumor growth, and for preventing emergencies.

But after treating thousands of patients, I’ve seen that removing the tumor does not automatically restore health. Cancer is the outcome of deeper imbalances throughout 

the body. The terrain—hormones, metabolism, inflammation, etc.—is what allowed it to grow. If the underlying contributors aren’t addressed, the body is still operating in the same environment that allowed the cancer to develop. 

On top of that, chemotherapy, radiation, and even major surgeries can be very hard on the body. They can weaken the immune system, lower metabolism, increase inflammation, and deplete nutrients. This weakened state can make it harder for the body to repair itself and can unfortunately create conditions that promote recurrence. 

A truly effective approach to cancer treatment must involve restoring the entire body. Cancer is a SYSTEMIC disease.

A few approaches that support the entire terrain of the body include: 

  1. Reducing tumor burden: Because chemo, radiation, and surgery are so hard on the body, many researchers and doctors have looked for gentler approaches to reducing the tumor burden. Research has shown that several therapies can slow tumor growth, improve treatment tolerance, and target cancer cell vulnerabilities without the same level of toxicity.
  • High dose vitamin C IV: At pharmacologic doses, vitamin C acts as a pro-oxidant in the tumor microenvironment, generating hydrogen peroxide that cancer cells cannot neutralize. This can slow tumor growth, improve quality of life, and does not target healthy tissues. 
  • Hyperthermia: Raising tissue temperature weakens cancer cells by stressing their already fragile mitochondria. Hyperthermia can make tumors more sensitive to other treatments and can directly slow growth by disrupting protein stability.
  • Repurposed drugs (Doxycycline, Fenbendazole, Ivermectin, Dichloroacetate, aspirin, etc.): These medicines were developed for other conditions but have mechanisms that disrupt cancer metabolism. Some block mitochondrial biogenesis, others interfere with microtubules or glycolysis, and some reduce inflammation. In combination with other treatments, they can meaningfully reduce growth pressure on the tumor.
  • Sodium bicarbonate (baking soda): Cancer cells create an acidic microenvironment by relying on glycolysis and producing excess lactic acid. Sodium bicarbonate helps neutralize this acidity, improving oxygenation and making the tumor less invasive. It can reduce metastasis potential and improve the effectiveness of other treatments.
  1. Balancing hormones: Hormones influence nearly every process in the body. They’re biochemical signals that interpret the internal terrain and tell tissues how to behave. High estrogen, high cortisol, prolactin, excess insulin, and growth-promoting hormones are frequently implicated in cancer. They respond to stressors by encouraging tissues to regenerate, but when these signals stay elevated, they create a constant growth-driven environment that supports cancer development. Balancing hormones is essential for restoring normal cell behavior. 
  • Natural progesterone (oral or topical): Progesterone directly opposes estrogen’s proliferative effects, lowers cortisol, reduces prolactin, supports thyroid function, stabilizes cell differentiation, and calms inflammation. In women (and sometimes in men), progesterone therapy helps counteract growth signals and creates a more regulated hormonal environment.
  • Pregnenolone: Pregnenolone used to help rebuild the body’s protective steroid pathways, oppose cortisol, support the brain and heart, reduce inflammation, and improve stress tolerance. It has also been shown to protect healthy cells from certain chemotherapy-related injuries. 
  • Thyroid hormones(T3/T4 therapy):The thyroid controls energy production, oxygen use, and cell differentiation. Using T3, T4, or combination therapy corrects low metabolic rate, lowers inflammation, and improves cell function. 
  • Anti-serotonin medications: Excess serotonin can raise prolactin, impair thyroid function, increase inflammation, and slow metabolism. Medications such as cyproheptadine are sometimes used to lower elevated serotonin activity, reduce prolactin, and shift the body away from stress physiology.
  • Anti-estrogens: These include aromatase inhibitors and selective estrogen receptor modulators, used when testing shows elevated estrogen activity. They help reduce estrogen-driven growth. 
  1. Repleting nutrients: Cancer places heavy metabolic demands on the body, and many patients start treatment already deficient in nutrients needed for energy production and healthy cell function. Repleting nutrients is a targeted medical approach to restoring the metabolic pathways that regulate inflammation, energy, and cellular function. When these deficits are corrected, patients typically tolerate treatment better and recover more efficiently. Here are just a few: 
  • High dose thiamine: Thiamine (vitamin B1) is essential for mitochondrial energy production and carbohydrate metabolism, which is severely impaired in cancer. High-dose thiamine can help bypass metabolic blocks, improve fatigue, support the nervous system, and stabilize glucose handling. 
  • Niacinamide: Niacinamide supports NAD⁺ production, which is central to mitochondrial function, DNA repair, and cellular resilience. Cancer and chemotherapy both drain NAD⁺ stores. Restoring niacinamide improves metabolic efficiency, lowers inflammation, stabilizes blood sugar, and protects healthy cells during treatment.
  • Vitamin D/K: Vitamin D regulates immune function, inflammation, and cell differentiation. Vitamin K works synergistically by directing calcium into tissues that need it and preventing calcification in places that do not. In combination, D and K help support immune surveillance, reduce inflammation, and maintain normal cell growth patterns. Many cancer patients are significantly deficient.
  • Magnesium: Magnesium is required for hundreds of enzymatic reactions, including ATP production, muscle function, nerve signaling, and inflammation control. Treatment, stress hormones, and poor intake rapidly deplete magnesium.
  1. Addressing infections and restoring gut function:  Many cancer patients come to the clinic with underlying bacterial, viral, or gut-related issues that place extra pressure on the immune system. These problems increase inflammation, raise cortisol, interfere with digestion and nutrient absorption, and force the immune system to stay chronically activated. When that happens, the body becomes less able to regulate hormones, control inflammation, or respond consistently to treatment. If they’re not treated, the body has a harder time responding predictably to cancer therapy. Identifying and treating these infections helps create a more stable baseline for the rest of the treatment plan.
  • Bacterial and viral infections: Chronic infections (such as H. pylori, periodontal pathogens, gut overgrowth, EBV, HSV, etc.) are common. Treatment may include targeted antibiotics such as amoxicillin or doxycycline or natural antivirals depending on the case. 
  • Parasites: Parasitic infections can impair nutrient absorption and contribute to inflammation. Options like Ivermectin or Fenbendazole can be helpful depending on the specific parasite. 
  • Endotoxin: Endotoxin is a toxic fragment released by certain gut bacteria. When the gut barrier is weakened, endotoxin enters the bloodstream and triggers systemic inflammation, higher cortisol, liver stress, and impaired thyroid function. Management may include activated charcoal to bind endotoxin, glycine to support the gut lining, and antibiotics if bacterial overgrowth is contributing to excess production.
  1. Restoring tissue oxygenation: Dr. Otto Warburg, a Nobel Prize–winning scientist, is best known for his work showing that cancer cells have a fundamental defect in how they use oxygen. His research established that when cells cannot efficiently utilize oxygen, they shift toward fermentation, a metabolic pattern now recognized as a hallmark of cancer. Many tumors exist in chronically low-oxygen environments, which further drives this metabolic shift. Improving oxygen delivery and utilization helps normalize metabolism, support healthier cell function, and make other therapies work more effectively.
  • Carbon dioxide therapy: Carbon dioxide improves oxygen delivery through the Bohr effect, helping hemoglobin release oxygen to tissues more efficiently. Increasing CO₂ can support better blood flow, improve mitochondrial function, and counteract the low-oxygen state common in stressed or inflamed tissues.
  • Hyperbaric Oxygen Therapy (HBOT): HBOT exposes the body to high-pressure oxygen, increasing the amount dissolved in the blood and delivered to tissues. This can improve wound healing, reduce inflammation, and enhance oxygen availability in areas where blood flow is limited.
  • Extracorporeal Blood Oxygenation and Ozonation (EBOO): EBOO circulates blood through a filtration and oxygenation system, exposing it to medical ozone. This increases oxygen delivery, reduces inflammatory byproducts, and may improve microcirculation.
  1. Lowering unnecessary stressors: Cancer arises as a result of severe, prolonged stress on the body. We cannot remove every stressor in someone’s life, but we can lower many of the pressures that keep the body in a constant state of activation. This helps balance hormones and regulate inflammation. These adjustments don’t replace treatment, but they make the body far more capable of responding to it.
  • Balancing blood sugar: Stable blood sugar lowers cortisol and reduces the need for the pancreas to release large amounts of insulin. Because insulin is a growth-promoting hormone, it can contribute to cancer. To balance blood sugar, patients pair protein with carbohydrates, eat regularly, and avoid long fasting windows that trigger cortisol spikes.
  • Eating enough calories: Consistently undereating raises cortisol, suppresses thyroid function, and lowers protective hormones like progesterone. Adequate calorie intake signals safety to the body, improves metabolic rate, stabilizes hormones, and reduces the stress physiology that can promote abnormal growth.
  • Improving the light environment: Light is one of the strongest regulators of human physiology. Darkness during the day is a persistent stressor. Natural morning light, on the other hand, helps lower cortisol, stabilizes circadian rhythms, and supports thyroid and metabolic function. 
  • Removing toxins (diet and personal care products): Toxins such as pesticides, plastics, synthetic fragrances, and xenoestrogens burden the liver and raise inflammation. Removing these exposures reduces the load on detox pathways. This includes switching to glass storage, fragrance-free products, clean personal care products, and minimizing pesticide exposure.
  1. Addressing traumas and emotional health: In my 39 years of practicing medicine, I have not met a patient who has not experienced some form of emotional stress. These experiences shape the nervous system and influence hormone patterns. The body responds to everything in our environment, including emotions, so it’s necessary to address the factors that keep the nervous system in a heightened state.
  • EVOX therapy: EVOX uses biofeedback and perceptual reframing to help the nervous system shift out of repetitive stress patterns. By calming the stress response, it can lower cortisol and improve physiological flexibility.
  • Journaling and free writing: Free writing is the practice of putting down your thoughts on paper without filtering, editing, or worrying about grammar. It allows us to process emotions and organize thoughts in a way that speaking sometimes cannot.  Writing forces us to organize what is happening in our mind and self-reflect. 
  • Connecting with nature: Nature has a unique effect on emotional regulation. Natural environments reduce sensory overload, quiet the parts of the brain involved in rumination, and help the nervous system shift out of heightened emotional reactivity. Sunlight stabilizes circadian rhythms and exposure to natural settings lowers sympathetic (fight-or-flight) activity. Together, these changes reduce cortisol, improve emotional processing, and help the body move out of the chronic stress states.

There are many ways to strengthen the body, support the immune system, and improve how tissues function during treatment. These approaches are not always discussed in standard care, but they can make a meaningful difference. Addressing the entire internal environment, the terrain in which cancer developed, is just as important as addressing the tumor.

Every patient is different, and treatment plans must be individualized. Still, there are well-studied therapies that improve cellular energy, regulate hormones, support detoxification, and help tissues function more normally. These interventions focus on stabilizing physiology, are generally nontoxic, and can help preserve quality of life during treatment.

When we treat the whole person, not just the tumor, we give the body the best chance to recover fully and prevent recurrence.

If you’ve been diagnosed with any type of cancer at any stage, looking for treatment for any health condition, or want to learn more about anti-aging, cancer prevention, total mind-body wellness, etc., please contact us at 949-680-1880 or visit www.centerfornewmedicine.com

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